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A: Existing studies report good safety profiles, but long-term data in humans is limited

An aliquot of 50 l urine sample was mixed with 120 l urease (10 mg/ml, 37 C, 60 min) to remove high content of urea

Dihydroethidium/hydroethidine (DHE) is a non-florescent probe that is oxidized by a variety of reactive oxygen and nitrogen species

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DNMT1 activity assay A radiometric assay was performed by RBC using 100 M 5 nM SAH as an inhibitor positive control

ONOO-is produced by cells that contain NOS enzymes, such as smooth muscle or endothelial cells, as well as by stimulated leukocytes during an inflammatory response