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To overcome the problem, prodrugs activated only after oral absorption were developed

10.1053/j.gastro.2019.01.252 Gastroenterology 77 LiJ.LiuL.LiuX.XuP.HuQ.YuY

In this context, their function often overlaps with that of selection biomarkers, as they help enrich trial populations with participants who are more likely to harbor the target pathology