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E has been studied to reduce the overall inflammation in the body thereby reducing the weight which justifies our results thus stating the impact of the dual therapy regime in the management of weight (Reference Saboori, Shab-Bidar and Speakman50Reference Bauer, Heinz and Whybrow52)

also, lipids and C-reactive protein levels increased by week 120, yet maintaining a significant difference with respect to patients on placebo 77

doi: 10.1016/S2468-1253(16)30119-4 116

In addition, the photoreceptor cells in diabetic mice also showed enhanced levels of iron, ROS, and MDA and reduced GSH concentration with downregulation of GPX4 and SLC7A11, and upregulation of ACSL4, FTH1 and NCOA4, which suggested that ferroptosis is also involved in the pathogenesis of photoreceptor degeneration in the development of the early stages of DR (Gao et al., 2023)