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Exposure to hyperglycemic dialysate induces oxidative stress-mediated cellular senescence

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Nat Rev Neurosci 14(1):3848

[DOI] [PubMed] [Google Scholar] 297.Salo P.M., Mendy A., Wilkerson J., Molsberry S.A., Feinstein L., London S.J., Fessler M.B., Thorne P.S., Zeldin D.C

Sources: STEP 1 Trial, Wegovy prescribing information, Novo Nordisk

B-cell lymphoma 2 (BCL-2) is a mitochondrial membrane protein that regulates apoptosis by blocking Bax- and Bak-mediated oligomerization in the outer mitochondrial membrane (OMM), thereby preventing cytochrome c release and caspase activation ( 2+ signaling, further contributing to the control of apoptosis ( Previous studies have highlighted the role of BCL-2 in intestinal epithelial injury