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383 A secondary analysis of the results showed, among subjects receiving canakinumab, those who achieved an hs-CRP level of less than 2.0 mg/L had 31% lower rates of cardiovascular and all-cause deaths, while those whose hs-CRP levels remained 2.0 mg/L or higher had no reduction in these outcomes

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333 It is reported that LRRK2 G2019S dopaminergic neurons exhibit a decreased NAD + pool and a reduced sirtuin deacetylase activity, correlating with elevated acetylation of sirtuin substrates p53, -tubulin and SOD2