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Acknowledgments We thank Simone Virus and Ute Widow for their excellent technical assistance

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After imaging the slices, we analyzed them using nanoscale secondary ion mass spectrometry (nanoSIMS)

The TB 500 peptide is used exclusively in research settings to study the biological activities attributed to the parent Thymosin Beta-4 protein, particularly its role in actin regulation, cell migration, and tissue repair processes the same regenerative, anti-inflammatory activity profile that places it on many a list of anti-inflammatory peptides researchers track

CYP3A4 predominantly catalyzed the formation of neferine-GSH conjugates, and GSH depletion significantly aggravated neferine-induced cytotoxicity (Shen et al., 2014)

We also used a competitive antigen-specific, T cell receptor (TCR)-dependent proliferation assay (OT-II) and a competitive homeostatic proliferation assay to assess T cell proliferation and differentiation in vivo