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The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice

System Xc- is a heterodimeric complex composed of the light chain SLC7A11 and the heavy chain SLC3A2, which mediates the 1:1 exchange of extracellular cystine for intracellular glutamate (Figure 2)