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Lipidomic analysis revealed distinct lipid profiles for M1 and M2 macrophages, as well as for M2 macrophages with HSL inhibition

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Future studies will validate in vivo modulation of WAT NAD + /SAM and delineate NAD + - and SAM-mediated epigenetic mechanisms that may underlie gene regulation in the presence of NNMT inhibitors

MOTS-c is a mitochondrial-derived peptide that plays a key role in regulating metabolic function, enhancing fat metabolism, and improving energy levels by optimizing mitochondrial efficiency