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Importantly, we here demonstrate that the REW substitutions strongly attenuate binding to SpA (Fig S5r, s), and accordingly, IgG1-REW could efficiently engage C1q, even in the presence of 5-molar excess of SpA, which prevented binding to WT IgG1 (Fig

This article traces that arc chronologically and cites the primary literature at each step

P., Long, F., Murshudov, G

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