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Generally, OH is formed from H 2 O 2 within the presence of iron or copper ions within the reaction described as well-known Fenton reaction (Fenton, 1984)

doi: 10.1016/j.clinbiochem.2006.02.009

10.1042/BJ20050979 Biochem

It must first be converted into DHF with the aid of vitamin B3 and then into THF also with the aid of vitamin B3

Nrf2: redox and metabolic regulator of stem cell state and function

830 The expression of ferroptosis-related genes is abnormal in renal tubular epithelial cells (TECs) after I/R injury, with the expression of ACSL4 is upregulated and correlating with renal function