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Science, Structure & Mechanism BPC 157 , formally known as pentadecapeptide BPC 157 , is a synthetic, partial sequence of Body Protection Compound a protein originally isolated from human gastric juice

Broom, L

doi:10.1038/s41591-024-03018-2 Coskun T, Urva S, Roell WC, et al

It is one of the most published research peptides with preclinical evidence across over 300 studies, predominantly from the University of Zagreb research group

It is marketed either alone, or in combination with vitamin C, N -acetyl cysteine, grape seed extract, alpha lipoic acid, and other antioxidants.[] When taken orally, it can be absorbed as an intact tripeptide from the gastrointestinal tract

Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]