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10.1016/j.jnutbio.2021.108634 34 JinL.SunS.RyuY.PiaoZ

Expanding adipose depots develop localized hypoxia that activates hypoxia-inducible factor 1- (HIF-1)-dependent signaling cascades, establishing self-perpetuating cycles of matrix accumulation

J.HuangX

Gen Comp Endocrinol (2010) 165:54956.10.1016/j.ygcen.2009.07.004 20 BehneDHoferTVon Berwordt-WallrabeRElgerW

Advances in the delivery of RNA therapeutics: from concept to clinical reality

Another mechanism by which pepsin can perpetuate its harmful effects is by reducing carbonic anhydrase-III levels, which play a fundamental role in local protection against the deleterious effects of stomach acid content (Reference Gill, Johnston and Buda34)