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2018;174:54963 e519

C.SampaioS

doi: 10.1038/nature06664 173 BillinghamLKStoolmanJSVasanKRodriguezAEPoorTASziborMet al

Fermentative production of l-alanyl-l-glutamine by a metabolically engineered Escherichia coli strain expressing l-amino acid alpha-ligase

Another challenge for nose-to-brain drug delivery is the development of appropriate delivery devices, since standard devices are optimized for local effects and therefore deliver only a small amount of drug to the olfactory region [65]

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