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However, randomised trials and meta-analyses do not show a uniform mortality benefit from higher protein provision, and very high early doses may be harmful in selected patients, particularly those with acute kidney injury or poor metabolic tolerance

However, lipid peroxidation can damage DNA, protein, lipids and eventually lead to cell death

Neuron 2 , 15471558 (1989)

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In this study, we have validated our animal model and the protective potential of DHEA by examining several parameters related to oxidative stress, inflammation, necrosis, and apoptosis, as well as evaluating the histological features of rats livers