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For example, the end product of heme metabolism, bilirubin, is eliminated through this pathway, which is catalyzed by the enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1)

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Degradation is gradual

In CUMS mouse models, Kai-Xin-San reduced LPS and pro-inflammatory cytokine levels while increasing tight junction protein expression in the gut and BBB, ameliorating depression-like behaviors through regulation of the gut microbiotainflammationstress system (Cao et al., 2020)

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Oxid Med Cell Longevity (2018) 2018:124