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Hypotension may be avoided by diluting sodium nitrite with normal saline and infusing the medication over a 20-min period with frequent blood pressure monitoring (Hall, 1986)

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Unfortunately, hope for a pan-cancer anti-angiogenic therapy [2] had been greatly diminished with the finding that the efficacy of vascular endothelial growth factor ( VEGF ) signaling pathway inhibitors is modest and is restricted to certain advanced-stage cancers only