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Results Inhibition of CD38 NADase by Ab68 treatment ameliorates skin and lung fibrosis Homeostasis of NAD + is governed by the action of the CD38 ecto-enzyme together with NNMT, which catalyzes the methylation of nicotinamide (NAM) generated via CD38 (Fig

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Neither route is backed by human clinical trial data, so any route advantage is extrapolated from animal pharmacology

P., Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J