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While our analyses controlled for key time-varying confounders (temporal order of the antipsychotic, schizophrenia-related hospitalization or emergency room visits within 3 months before the starting date of the subperiod, etc.), we cannot rule out the possibility of unobserved time-varying confounders (e.g., changes in non-psychiatric or psychiatric symptoms and severity, consumption of co-medications) that our analyses did not control for and could still bias our study results

Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID

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SIRT1 is widely expressed in normal renal tubular cells and podocytes, but decreases with renal diseases or ageing (Lim et al., 2012)