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SIRT1 protects dopaminergic neurons in Parkinsons disease models via PGC-1-mediated mitochondrial biogenesis

Model Selection: In vitro: 3T3-L1 adipocytes, primary adipocytes Ex vivo: Adipose tissue explants In vivo: DIO models, body composition assessment 5

Created from Divito et al.13

Common Side Effects Pain, redness, swelling, or bruising at the injection site Tingling or numbness in your fingers, toes, or skin Flushing or feeling warm Dizziness or spinning sensation Fatigue or weakness Nausea or vomiting Unpleasant taste in your mouth These are generally mild and should go away on their own

Parkinsonism-inducing neurotoxin,N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metaboliteN-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

10.1016/S0304-3959(00)00284-0 103 LengertN.DrosselB