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In AD, reduced pineal size, pineal gland dysfunction, and pineal calcification have been reported [38], and decreased melatonin levels have been detected in serum [64] and urine [65]

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Antioxid Redox Signal 32(18):13301347

Its relatively compact molecular weight confers favorable tissue permeability and efficient systemic absorption in biological environments, supporting its potential for effective delivery and action within the body

Deg-AZM was widely distributed in the tissues without obvious accumulation, and mainly excreted from the urinary excretion pathway