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The role of catalase in mitigating oxidative stress underscores its utility as a therapeutic avenue in a spectrum of pathological states characterized by increased reactive oxygen species (ROS) production (Figure 1 and Figure 2)

Neurochem Int 60(7):662671 Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, OBrien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M (2013) Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure

One important reason is that DTP cells can survive under the action of chemotherapeutic drugs and enter a low proliferation state, just like embryos in diapause, thereby evading drug killing (39, 51, 52)

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This mode of administration has been widely validated by studies on the efficacy of APAP

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