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At day 11 , mice (n=6 animals per group) were treated with tested conjugates (10 mg/kg i.p.) and were monitored for apparent signs of toxicity and weight loss during the duration of the experiment

& Waugh, D

J Mol Biol 2007;367:395-408

Despite the lack of evidence, manufacturers of IV GSH have been recommending a dose of 6001200 mg, to be injected weekly or twice a week, with no specified net duration of the therapy [8]

GSH concentrations were significantly reduced in the sh-GCLC group compared to the control group, indicating impaired antioxidant capacity due to GCLC inhibition

EOAD patients generally exhibit higher Neuropsychiatric Inventory (NPI) scores, indicating more severe symptoms, and a higher prevalence of depression, anxiety, apathy, eating problems, and agitation (Falgs et al., 2021