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First, about 90% of the drug is processed by the body through a process called glucuronidation, which does not produce dangerous byproducts

useful candidate compounds are degraded at least 2, 4, 10 or 100 times faster in the cell (or under in vitro conditions selected to mimic intracellular conditions) as compared to blood (or under in vitro conditions selected to mimic extracellular conditions)

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Triplet CFTR modulators: future prospects for treatment of cystic fibrosis

At present, targeted detection of metabolites altered in blood include amino acids (tyrosine, tryptophan, arginine, proline, methionine, cysteine, and taurine), lipids (phospholipids, sphingolipids, and fatty acids), and metabolites in the urea cycle and xenobiotics metabolism