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J Diabetes Investig 5:621622

With B12, as with many nutrients, the goal is not as much as possible

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Excretion Pathways Excretion mechanisms for both peptides remain incompletely characterized: Renal filtration likely represents primary elimination route for peptide fragments Hepatic metabolism may contribute to peptide degradation and clearance No evidence of significant biliary excretion in available studies Pharmacokinetic studies in renal or hepatic impairment models are absent from literature The rapid systemic clearance of both peptides contrasts with prolonged downstream effects on growth hormone and IGF-1, indicating that direct peptide presence is not required for sustained biological activity once pituitary signaling cascades are initiated

In fact, theres a high prevalence of low serum vitamin B12 among vegetarians, in particular vegans, where prevalence ranges at levels between 43% and 88%.6 Going back as far as 1955, studies have shown that vegans have experienced vitamin B12 deficiency.7 In addition, B12 crosses the placenta during pregnancy and is present in breast milkthus, if the mother doesnt receive adequate B12 intake, infants may suffer from B12 deficiency, which can lead to severe, permanent neurological damage.4 Norris says the story doesnt end there

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