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Although Serum B12 showed a downward trend with the increase of MMA level, B12 in most patients is still higher than the cutoff value of B12 deficiency ( 250 nmol/L, about 47% had serum B12 more than 400 pg/mL

In: Stoker TB, Greenland JC, eds

61 JohnstonC

Regular and sustained use of MIC B12 injections is often recommended rather than a one-time treatment for effective results

Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

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