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57 As many MPNSTs in NF1 patients have mutations in components of the PRC2 complex, which negatively regulates gene expression through histone methylation (H3K27Me) resulting in histone acetylation (H3K27Ac), inhibiting BRD4 might be particularly effective

Como consecuencia, el enlace promueve la estabilidad intracelular ya que el tripptido slo puede ser degradado extracelularmente por la enzima GGT

doi: 10.3389/fimmu.2025.1653803 Received 25 June 2025 Accepted 29 October 2025 Published 11 November 2025 Volume 16 - 2025 Edited by Oscar Herrera-Calderon, Universidad Nacional Mayor de San Marcos, Peru Reviewed by Cristopher Anel Boya, Instituto de Investigaciones Cientficas y Servicios de Alta Tecnologa, Panama Salyoc Tapia-Rojas, Universisdad Cientifica del Sur, Peru Updates Copyright 2025 Fekete and Pzmndi