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Labwork at that time was notable for an elevated uric acid of 10.6mg/dl (reference range: 3.5 - 8.5 mg/dl.) Out of concern for TLS precipitating hyperuricemia in the setting of a high-grade tumor in addition to starting a new chemotherapy regimen, the patient was additionally given 10mg of rasburicase and started on 300mg of allopurinol daily

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10.1038/nrc3711 25 BiswasS

Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins