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149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

doi: 10.1186/s12915-022-01325-z 86 HiltonB

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9 Maintaining an optimal equilibrium between the overall oxidation status and the bodys antioxidant response is crucial for a balanced genomic system

Supporting glutathione during this time may help women enter the transition with more resilience [19]

supporting the feasibility of treat-smart personalized therapy rather than non-specific escalation