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Description

6.2 GPx and obesity Obesity promotes the storage of triglycerides in adipose tissue

The detection threshold was set to 3 times the noise s.d

This pathway has been studied in several in vitro models and is under investigation as a potential therapeutic target in several cancers, including breast, ovarian, liver, and prostate 15,16,17,23

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway

In addition, -KG is exported from mitochondria through SLC25A11 to the cytosol 21 and then participates in fatty acid biosynthesis and NADH generation 22 (Fig