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Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation

This is a little bit of stressful challenge that activates these stress response pathways in a beneficial way that is a net positive, that actually has a very profound antioxidant, anti-inflammatory response, or whatever the response is

, Lindsay C

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Endothelial Glycocalyx

61 Li et al 128 used a cyclic heating and cooling treatment to prepare semi-IPN bioinks with excellent shear-thinning properties, which dramatically improved cell activity while ensuring the high resolution of the scaffolds