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Even class II GRXs AtGRXS15, AtGRXS16 and HsGRX5 can catalyse the oxidation of roGFP2 by GSSG, although they fail to mediate its reduction 13,14,50

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This challenge was addressed by replacing disulfide linkages with 3-sulfanylpropionyl ester linkages that are sensitive to the acidic pH of endosomes

J Biochem Mol Toxicol 16, 31725

sanfranciscensis were found to be several folds higher for cells supplemented with GSH as compared to cysteine supplemented cells and control culture [80]