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Furthermore, SAC is 30 fold less toxic than other garlic components, such as allicin and diallyl disulfide, and relatively inexpensive and easy to synthesize [17]

The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns

In OA, fibroblast-like synoviocytes and synovial macrophages acquire a pro-inflammatory phenotype, secreting high levels of cytokines and chemokines and prostaglandins, together with matrix-degrading enzymes and nitric oxide

2022 Mar;16(3):102447