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Introduction Neuropsychiatric disorders carry a significant burden and disproportionally affect more women than men (Wittchen et al., 2011)

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Semaglutide: Linear polypeptide PEPTIDE SEQUENCE Cagrilintide: ?Glu-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH 2 Semaglutide: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH CHEMICAL STRUCTURE Cagrilintide: Semaglutide: CHEMICAL STRUCTURE Cagrilintide: C 194 H 312 N 54 O 59 S 2 Semaglutide: C 187 H 291 N 45 O 59 Mechanism of Action Cagrilintide acts primarily as a long-acting amylin analogue, stimulating amylin and calcitonin receptors to promote satiety, slow gastric emptying, and suppress postprandial glucagon release

doi: 10.3390/molecules26113421 172

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Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)