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J Immunol 127: 22572262

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doi: 10.1007/s00125-013-3093-8 76 BatliwalaSXavierCLiuYWuHPangIH

COVID-19/phase-III: thrombocytopenia Acute COVID-19 due to severe iron toxicity from oxidized iron could modulate several systemic pathways of coagulation cascade and cause thromboembolism 99

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Concurrently, elevated pyruvate kinase M2 (PKM2) expression upregulates Bcl-xL [59], while mesenteric adipose tissue (MAT) and lamina propria lymphocytes (LPL) show characteristic apoptotic dysregulation with increased Bcl-2 and decreased BAX expression [60, 61]