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Alternative strategies that could bypass genetic transformation should be adopted to deliver CRISPR/Cas machinery into Egusi cells

The presence of proteoglycans expressed on endothelial cells results in a negative charge of the BBB luminal side and, consequently, the development of positively charged NPs can improve the intracellular delivery of therapeutics exploiting the AMT mechanism (Herv et al., 2008)

Nineteen-year follow-up of a patient with severe glutathione synthetase deficiency

Integrating other signalling modules and hormonal signalling is also connected with the calcium signalling pathway (Trotta et al., 2014)

Arnold, O

The targets of current GSH depleting agents are mainly located in the cytosol or cell membrane, as the cytosol is the central hub for GSH biosynthesis (Figure 2)