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All experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of RASTA Special Research Institute (RSRI) (Approval Number: RSRI/UU/13252024), and the study adhered to the guidelines established by the National Institutes of Health for the care and use of laboratory animals

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Studies using neuronal cell cultures have shown that IGF1 LR3 protects against many forms of cellular stress, including oxidant stress, excitotoxicity, and apoptotic stimuli

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