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NADPH has the effect of eliminating reactive oxygen species (ROS) in the body, and IDH1 mutation weakens its ability to eliminate ROS

doi: 10.3390/molecules21091216 144

Wilhelm Filho D, Avila S, Jr., Possamai FP, et al

On the other hand, melatonin has an apoptotic cytotoxic effect on myeloid cell lines HL-60, B lymphoma, MCF-7, prostate cancer cells LNCaP, or hepatocarcinoma HepG2 [43]