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They also may be more likely than antiestrogens to cause multiple pregnancies, such as with twins, and ovarian hyperstimulation syndrome

doi: 10.1038/nn.3691 197 TnnesenJ.InavalliV

However, some patients will go to great lengths to continue using topical anesthetics despite the damage

Many cancer cells adapt to stressful conditions by upregulating stress-buffering proteins such as glucose-regulated protein 78 (GRP78), 158 which dampens ER stress signaling, or activating nuclear factor erythroid 2related factor 2 (Nrf2)-mediated antioxidant pathways to suppress ROS accumulation, 159 thereby blunting DAMP release even in response to ICD-inducing agents

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