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discovered that the lactylation of NBS1 at lysine 388 (K388) can promote the accumulation of the MRN complex and HR proteins at the site of DNA double-strand breaks (DSBs), thereby facilitating DNA damage repair, which is frequently associated with poor outcomes of tumor patients undergoing neoadjuvant chemotherapy [27]

Leuk Lymphoma 63(13):1-12, 2022

Out of the 21 included studies six were excellent (38, 39, 4245), 12 were scored as good (35, 37, 40, 4654), and three were fair (34, 36, 41)

Aggressive afterload lowering to improve the right ventricle: a new target for medical therapy in pulmonary arterial hypertension

Hanahan D and Weinberg RA

Regarding clinical outcomes, hospitalization was the most common outcome (n = 3,336, 11.5%), while death (n = 234, 0.8%) and life-threatening events (n = 354, 1.2%) occurred less frequently