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On the other hand, the generation of microbleeds due to cerebral hypoxia, brain trauma, aneurysms, hemorrhagic stroke, or due to the seizures themselves, will produce the intra-tissue accumulation of hemoglobin, activation of hemoxygenase 1 (HO-1) and release of high amounts of iron and hemosiderin accumulation, that acts itself as factor inducing seizures as observed in cavernomas [36, 76] or brain tumors [77] (Figure 1)

Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns

Marletta AS, Massarotti A, Orsomando G, Magni G, Rizzi M, Garavaglia S (2015) Crystal structure of human nicotinic acid phosphoribosyltransferase

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Accordingly, several approaches have been used to reduce the risk of PAHs formation by employing safe processing systems, harmless cooking methods, marination by natural plant components, use of biological methods etc