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Most of the early studies focused on its effects on the stomach and intestines

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Intern Med

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From all the reading Ive done, Ive only ever heard mention of acid hydrolases that become active at lysosomal pH, so pH 5.0 or so see for instance [Cooper 2000 Chapter 9 - Lysosomes]

Chromatin immunoprecipitation results show that inhibition of HDAC3 enhances the binding of acetylated histone H3 to the DUSP5 promoter [156]