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Neuronal injury subsequent to cerebral ischemia plays a pivotal role in the progression of ischemic brain damage, with its underlying mechanisms encompassing a spectrum of interconnected processes, including energy metabolism failure, excitotoxicity mediated by amino acid neurotransmitters, intracellular calcium overload, oxidative stress, and the activation of apoptotic signaling cascades

Dey P, Kundu A, Kumar A, et al

& Akhondi, M

This effect is mediated through the downregulation of GRP78 and CHOP in the colon of IUGR piglets [147]

doi: 10.1038/414799a 9

Thus, unraveling the genetic mechanisms underlying salt stress tolerance could provide important clues to improve crop fitness and yields under prolonged salinity stress or in the regions with high soil salinity