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This expansion leads to FMR1 promoter silencing via an epigenetic mechanism involving DNA methylation of the CGG repeat region and adjacent regulatory areas (216)

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Almeer R.S., AlBasher G.I., Alarifi S., Alkahtani S., Ali D., Abdel Moneim A.E

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That development culminated in a peer reviewed pilot study published in the journal Redox Biology

Notably, rats show a twofold rise in A protein levels and APP expression levels after six weeks of intraperitoneal administration of scopolamine

Although our studies have focused on hepatic proteins, our approach should be amenable for characterizing the mechanisms of organ damage in other tissues