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Crystals of wild-type mIDH2 were obtained at 4 C with a reservoir solution consisting of 0.1 M sodium citrate tribasic dehydrate (pH 5.6), 11.5% (v/v) 2-propanol and 10.8% (w/v) PEG 4000

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doi: 10.1016/j.bbi.2014.07.002 135 MillerA

30 made similar observations in HEK293 cells where Torin inhibited expression of several ATF4 target genes

A salient issue pertains to the limited sample sizes frequently observed in these trials, which often result in inadequate follow-up durations and the absence of histological validation to substantiate outcomes pertaining to the liver

Larger injection volumes (12mL) are more forgiving of small measurement errors than tiny volumes (0.30.5mL), where a 0.1mL miscalculation represents a 2033% dose variation