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doi: 10.3389/fmicb.2022.1020995 Summary Keywords periodontitis, ferroptosis, cuproptosis, oxidative stress, glutathione, autophagy Citation Zheng T, Lu F, Wu P, Chen Y, Zhang R and Li X (2025) Ferroptosis and cuproptosis in periodontitis: recent biological insights and therapeutic advances

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Activated microglia release nitric oxide and other mediators that, when combined with superoxide, form peroxynitrite, a highly reactive species capable of damaging proteins, lipids, and DNA