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Meanwhile, earlier studies often relied on membrane potential dyes such as MitoTracker [330] and TMRM [363] to trace mitochondria, but these dyes can themselves transfer between cells or disrupt mitochondrial function, leading to false positives resembling mitochondrial transfer

EC Nutrition, 8 , 152159

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury