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[DOI] [PMC free article] [PubMed] [Google Scholar] [199].Cheff DM, Huang C, Scholzen KC, et al

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Additionally, SAM plays a pivotal role as the primary provider of methyl groups, which are crucial for various processes, including gene regulation

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Inhibition of phospholipase D 1/2 (PLD1/2) blocks ROS accumulation, iron metabolic disorders, and NLRP3 activation simultaneously, indicating that both processes share upstream regulatory nodes controlled by the PLD signaling pathway