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He observed that plasma of young adults stimulates growth and regeneration of liver cells , whereas plasma of older subjects lost this effect

Int J Mol Sci 21: 3550, 2020

Results from the phase 2 TROPION-Lung05 trial published in the Journal of Clinical Oncology revealed that among 137 patients given 6 mg/kg of dato-DXd every 21 days for pretreated NSCLC, the confirmed ORR was 35.8% (95% CI, 27.8%-44.4%), including 32.8% of patients experiencing a partial response and 2.9% having a complete response

Recently, Sparreboom et al

The further treatment regimen included a daily dose of vitamin B12 injection for seven consecutive days, followed by weekly injections for the next four weeks, and then monthly injections

I would give proper loading doses of buprenorphine, followed by the usual adjuncts if needed (clonidine being the most relevant here, but also ondansetron, hydroxyzine, benzos, as appropriate)