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We previously demonstrated that RMC exhibits a hot immune-inflamed phenotype characterized by upregulation of immune checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) in the tumor immune microenvironment 10

With MD simulations of reasonable quality and in agreement with the protein dynamics in solution on the microsecond timescale, it becomes meaningful to use the MD ensembles to study the effects induced by phosphorylation and unveil new details of the underlying mechanism

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10.1016/j.ijcard.2017.05.086 47 DuanD.FanT.ZhangL.LiL.WangH.GuoM.et al (2023)

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MiR-134 inhibits infiltration of trophoblast cells in placenta of patients with preeclampsia by decreasing ITGB1 expression