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These polyphenolic metabolites exhibit a wide range of bioactivities and can exert certain physiological or pharmacological effects on organisms, including antioxidant, anti-inflammatory, and antibacterial activities (Table 2)

Significant to COVID-19, ACE2 has been established as the functional host receptor for SARS-CoV-2, and many factors have proved to be associated with both altered ACE2 expression and disease severity and progression, including age, sex, ethnicity, medication, and several co-morbidities (such as cardiovascular disease, metabolic syndrome, and lung cancer) ()

Haemmerle, M., Taylor, M

Intestinal Metals Detox (IMD): A proprietary and highly purified silica, IMD binds mercury and other heavy metals to escort them out of the body through the gut

Funding This study was financially supported by statutory funds of the Maj Institute of Pharmacology, Polish Academy of Sciences, Krakw, Poland

Because the betaine pathway metabolizes homocysteine into methionine, betaine administration may be more effective than SAM administration in treating ALD (34)